Malignant TOXication of T cells

Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells.

Studies in an in vitro model of cutaneous T-cell lymphoma (CTCL) demonstrated that CTCL cell proliferation is stimulated by direct contact with autologous, immature dendritic cells (DCs), suggesting that CD4(+) CTCL cell division is driven by antigens presented by DC major histocompatibility complex (MHC) class 2. We now report that the T-cell receptor (TCR) of the CD4(+) CTCL cells is triggere...

High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma.

In early-stage cutaneous T-cell lymphoma (CTCL), malignant T cells are confined to skin and are difficult to isolate and discriminate from benign reactive cells. We found that T cells from CTCL skin lesions contained a population of large, high-scatter, activated skin homing T cells not observed in other inflammatory skin diseases. High-scatter T (T(HS)) cells were CD4(+) in CD4(+) mycosis fung...

Malignant T cells activate endothelial cells via IL-17 F

Surface antigens on malignant Sézary and T-CLL cells correspond to those of mature T cells.

Tumor cells from eight adult patients with T-cell chronic malignancies were investigated with a series of monoclonal antibodies recognizing T-cell differentiation antigens. This series allowed definition of discrete subpopulations of mature T cells with functional specialization. All six patients with Sézary syndrome and one patient with T-chronic lymphocytic leukemia had cells with the same ph...

Fish Poisoning: A Problem in Food Toxication

INTEREST IN POISONOUS FISHES has intensified greatly in recent years. World Wat II brought many Americans and Europeans to tropical areas of the world where fish poisoning is common. Also, interest in the welfare of native populations of the Pacific islands has developed widely, and there is an impression that fish poisoning is increasing. In spite of an extensive literature, there is considera...